SteeraMed Bench · Nomination Leaderboard

Nomination Leaderboard

Every nomination is scored under the same frozen protocol (332 modules x 1,916 small molecules, permutation tests + BH correction). The primary verdict is incremental value — a gene set having signal on its own is not the same as adding independent increment to the atlas.

Combo Contribution Board: explain / intervention / mixed — existing modules compete

Snapshot: v2026.W34r2 · 2026-08-19T15:40:51Z

Feature preview release — data and UI are under rapid iteration; published snapshots define the reporting protocol.

Track B · Gene-set nominations (submit a gene list)

2 nominations

#	Concept	Single-module Recall@20	Atlas increment	q (BH)	Verdict	Nearest atlas module	In-family evaluation
1	Clonal hematopoiesis of indeterminate po…Human-curated	0.040	-0.010	0.045	no independent increment over full atlas	YFY:薏苡仁 r = 0.50	Hallmarks +0.010
2	Senescence-associated secretory phenotyp…Human-curated	0.010	+0.010	0.440	nominal single-module gain, not significant	YFY:乌梢蛇 r = 0.74	Hallmarks 0.000

Definitions: single-module Recall@20 = ranking ability of the gene set alone as a panel; atlas increment = (full 332-module atlas + nomination) - full atlas. q values are jointly BH-corrected across all nominations in the batch. Historical snapshots are never rewritten; every result permanently carries the version it was published in.

Track A · Concept nominations (LLM-expanded)

7 nominations

#	Concept	Single-module Recall@20	Atlas increment	q (BH)	Verdict	Nearest atlas module	In-family evaluation
1	Lysosomal membrane permeabilizationAI-proposed	0.050	+0.010	0.045	single-module signal significant (BH); increment positive	YFY:决明子 r = 0.27	Hallmarks +0.010
2	NAD+ salvage and recyclingAI-proposed	0.040	+0.021	0.045	single-module signal significant (BH); increment positive	Hallmarks:A1_mitochondrial r = 0.47	Hallmarks 0.000
3	ECM stiffening & mechanotransductionAI-proposed	0.020	+0.020	0.146	nominal single-module gain, not significant	NUT:Clove oil r = 0.56	Hallmarks +0.030
4	Senescent macrophage (p21-TREM2 axis)AI-proposed	0.010	+0.020	0.440	nominal single-module gain, not significant	Hallmarks:A1_senescence r = 0.59	Hallmarks +0.020
5	Clonal hematopoiesis of indeterminate po…AI-proposed	0.000	0.000	1.000	no independent increment over full atlas	YFY:薏苡仁 r = 0.72	Hallmarks +0.010
6	Ferroptosis defense mechanismsAI-proposed	0.000	+0.011	1.000	nominal single-module gain, not significant	NUT:NADH r = 0.51	NUTX -0.010 · ⇄ Glutathione
7	Tissue-resident macrophage efferocytosisAI-proposed	0.000	-0.010	1.000	no independent increment over full atlas	Hallmarks:A1_senescence r = 0.60	Hallmarks 0.000 · ⇄ A2_blood_vessel

In-family boards · compared within the same series

At prediction time modules are not used as one pool of 332; they are compared within the same series. A newly nominated aging hallmark is evaluated alongside the existing aging-hallmarks family; a new nutrient or food-as-medicine module first finds its most similar sibling in the series, then tests whether it can replace it.

Hallmarks family board · new aging-hallmark nominations

8 nominations

#	Concept	Family incr.	Replace Δ	Single-module q (BH)	Family verdict	Nearest atlas module
1	ECM stiffening & mechanotransductionAIHallmarks	+0.030	⇄ +0.030	0.146	family-additive	NUT:Clove oil r = 0.56
2	Senescent macrophage (p21-TREM2 axis)AIHallmarks	+0.020	⇄ +0.020	0.440	family-additive	Hallmarks:A1_senescence r = 0.59
3	Lysosomal membrane permeabilizationAIHallmarks	+0.010	⇄ +0.020	0.045	family-additive	YFY:决明子 r = 0.27
4	Clonal hematopoiesis of indeterminate po…HumanHallmarks	+0.010	⇄ 0.000	0.045	family-additive	YFY:薏苡仁 r = 0.50
5	Clonal hematopoiesis of indeterminate po…AIHallmarks	+0.010	⇄ 0.000	1.000	family-additive	YFY:薏苡仁 r = 0.72
6	NAD+ salvage and recyclingAIHallmarks	0.000	⇄ -0.010	0.045	family-none	Hallmarks:A1_mitochondrial r = 0.47
7	Senescence-associated secretory phenotyp…HumanHallmarks	0.000	⇄ 0.000	0.440	family-none	YFY:乌梢蛇 r = 0.74
8	Tissue-resident macrophage efferocytosisAIHallmarks	0.000	⇄ 0.000	1.000	family-replaceable	Hallmarks:A1_senescence r = 0.60

Definitions: family increment = recall(closest family + nomination) − recall(closest family), 5-disease mean; replace Δ = recall(family − most-similar sibling + nomination) − recall(family), ≥0 means swapping that sibling costs nothing (⇄). Family verdict: family-additive / family-replaceable / family-none. Note: the family verdict follows a three-state mean rule without a significance test on the family increment; the q column is the single-module (vs full map) BH q value, shown for reference only.

Intervention board · nutrients / food-as-medicine / TCM

1 nominations

#	Concept	Family incr.	Replace Δ	Single-module q (BH)	Family verdict	Nearest atlas module
1	Ferroptosis defense mechanismsAINUTX	-0.010	⇄ +0.030	1.000	family-replaceable	NUT:NADH r = 0.51

Reference board · Auto-scanned public gene sets

57 reference gene sets

#	Concept	Single-module Recall@20	Atlas increment	Nearest atlas module
1	HP_ST_SEGMENT_DEPRESSION 14 genes · depression	0.110	+0.020	Hallmarks:A2_heart r = 0.41
2	GOBP_REGULATION_OF_SYSTEMIC_ARTERIAL_BLOOD_PRESSURE 124 genes · hypertension	0.090	0.000	YFY:白扁豆 r = 0.44
3	KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 82 genes · aging	0.090	0.000	Hallmarks:A1_proteostasis r = 0.38
4	HP_INSULIN_RESISTANCE 113 genes · diabetes	0.080	+0.010	NUT:ATP r = 0.46
5	DOID_0060167 25 genes · depression	0.080	0.000	NUT:Ephedra sinica root r = 0.53
6	SUMI_HNF4A_TARGETS 35 genes · atherosclerosis	0.070	+0.020	NUTX:SAMe r = 0.46
7	KEGG_TYPE_II_DIABETES_MELLITUS 61 genes · diabetes	0.070	0.000	Hallmarks:A2_thymus r = 0.49
8	GO_0008217_9606 69 genes · hypertension	0.070	0.000	YFY:高良姜 r = 0.46
9	WP_NAD_METABOLISM_IN_ONCOGENEINDUCED_SENESCENCE_AND_MITOCHONDRIAL_DYSFUNCTIONASSOCIATED_SENESCENCE 25 genes · aging	0.060	+0.010	Hallmarks:A3_uric_acid r = 0.49
10	WP5181 23 genes · diabetes	0.060	0.000	YFY:阿胶 r = 0.65
11	KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 29 genes · diabetes	0.050	+0.030	NUT:Lipoic acid r = 0.42
12	HP_MATERNAL_DIABETES 45 genes · diabetes	0.050	+0.021	NUT:alpha-Linolenic acid r = 0.31
13	HP_RENOVASCULAR_HYPERTENSION 30 genes · hypertension	0.050	0.000	NUT:Clove oil r = 0.46
14	HP_ELEVATED_DIASTOLIC_BLOOD_PRESSURE 14 genes · hypertension	0.050	0.000	YFY:高良姜 r = 0.52
15	REACTOME_OXIDATIVE_STRESS_INDUCED_SENESCENCE 126 genes · aging	0.050	0.000	YFY:薏苡仁 r = 0.66
16	WP_ROLES_OF_CERAMIDES_IN_DEVELOPMENT_OF_INSULIN_RESISTANCE 26 genes · diabetes	0.050	-0.010	YFY:阿胶 r = 0.63
17	BIOCARTA_LONGEVITY_PATHWAY 17 genes · aging	0.050	-0.010	YFY:乌梢蛇 r = 0.62
18	ASTON_MAJOR_DEPRESSIVE_DISORDER_UP 51 genes · depression	0.040	+0.011	Hallmarks:A3_uric_acid r = 0.50
19	HP_MATURITY_ONSET_DIABETES_OF_THE_YOUNG 23 genes · diabetes	0.040	+0.010	Hallmarks:A2_prostate r = 0.42
20	HP_TYPE_II_DIABETES_MELLITUS 156 genes · diabetes	0.040	0.000	Hallmarks:A2_prostate r = 0.43
21	WP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION 39 genes · depression	0.040	0.000	NUT:Taurine r = 0.52
22	GO_0030501_9606 39 genes · osteoporosis	0.040	0.000	Hallmarks:A1_microbiota r = 0.46
23	WP_SREBF_AND_MIR33_IN_CHOLESTEROL_AND_LIPID_HOMEOSTASIS 18 genes · atherosclerosis	0.030	0.000	NUT:Coenzyme A r = 0.53
24	WP2011 16 genes · atherosclerosis	0.030	0.000	NUT:Coenzyme A r = 0.53
25	WILCOX_RESPONSE_TO_PROGESTERONE_UP 165 genes · atherosclerosis	0.030	0.000	Hallmarks:A1_senescence r = 0.42
26	GOBP_REGULATION_OF_BONE_MINERALIZATION 86 genes · osteoporosis	0.030	+0.011	Hallmarks:A2_bone r = 0.48
27	GOBP_POSITIVE_REGULATION_OF_BONE_MINERALIZATION 47 genes · osteoporosis	0.030	+0.011	Hallmarks:A2_bone r = 0.38
28	REACTOME_ONCOGENE_INDUCED_SENESCENCE 38 genes · aging	0.030	+0.011	YFY:薏苡仁 r = 0.55
29	WP_NAD_METABOLISM_SIRTUINS_AND_AGING 11 genes · aging	0.030	+0.010	YFY:薏苡仁 r = 0.58
30	KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_DN 199 genes · aging	0.030	+0.010	Hallmarks:A2_liver r = 0.24
31	GOBP_REGULATION_OF_LONG_TERM_SYNAPTIC_DEPRESSION 20 genes · depression	0.030	0.000	NUT:Taurine r = 0.61
32	REACTOME_SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP 112 genes · aging	0.030	0.000	YFY:薏苡仁 r = 0.70
33	WP_GLYCOLYSIS_IN_SENESCENCE 15 genes · aging	0.020	+0.011	Hallmarks:A3_uric_acid r = 0.43
34	WP_SPHINGOLIPID_METABOLISM_IN_SENESCENCE 29 genes · aging	0.020	+0.011	Hallmarks:A2_thymus r = 0.47
35	DOID_9352 13 genes · diabetes	0.020	+0.010	Hallmarks:A1_microbiota r = 0.48
36	ASTON_MAJOR_DEPRESSIVE_DISORDER_DN 174 genes · depression	0.020	+0.010	NUTX:Taurine r = 0.37
37	KYNG_NORMAL_AGING_DN 18 genes · aging	0.020	+0.010	YFY:薏苡仁 r = 0.44
38	WP_BEMPEDOIC_ACID_THERAPY_IN_ATHEROSCLEROSIS_AND_METABOLIC_SYNDROME 28 genes · atherosclerosis	0.020	+0.001	YFY:乌梢蛇 r = 0.57
39	WILCOX_RESPONSE_TO_PROGESTERONE_DN 65 genes · atherosclerosis	0.020	+0.001	NUT:Fish oil r = 0.32
40	DOID_0050470 12 genes · diabetes	0.020	0.000	NUTX:Chromium r = 0.51
41	GO_0003073_9606 10 genes · hypertension	0.020	0.000	NUTX:Inositol r = 0.39
42	HP_LOCALIZED_OSTEOPOROSIS 24 genes · osteoporosis	0.020	0.000	Hallmarks:A2_breast r = 0.30
43	KYNG_NORMAL_AGING_UP 17 genes · aging	0.020	0.000	TCM:T2_heart_tcm r = 0.37
44	WP_TCA_CYCLE_IN_SENESCENCE 18 genes · aging	0.020	0.000	Hallmarks:A3_uric_acid r = 0.53
45	LY_AGING_PREMATURE_DN 31 genes · aging	0.010	+0.020	Hallmarks:A1_senescence r = 0.45
46	GO_0030502_9606 12 genes · osteoporosis	0.010	+0.011	NUT:Calcium r = 0.48
47	HP_MATERNAL_HYPERTENSION 10 genes · hypertension	0.010	+0.010	NUT:Clove oil r = 0.35
48	GO_0030500_9606 17 genes · osteoporosis	0.010	+0.010	NUT:Thiamine r = 0.54
49	HP_PRECOCIOUS_ATHEROSCLEROSIS 12 genes · atherosclerosis	0.010	+0.010	Hallmarks:A1_extracellular_matrix r = 0.35
50	GO_0042632_9606 96 genes · atherosclerosis	0.010	+0.010	Hallmarks:A1_microbiota r = 0.47
51	DOID_12603 67 genes · aging	0.010	+0.010	Hallmarks:A2_pleura r = 0.28
52	HALLMARK_CHOLESTEROL_HOMEOSTASIS 82 genes · atherosclerosis	0.010	0.000	YFY:山药 r = 0.43
53	BIOCARTA_LEPTIN_PATHWAY 11 genes · diabetes	0.000	+0.020	YFY:薏苡仁 r = 0.39
54	DOID_9478 10 genes · depression	0.000	+0.020	NUT:Taurine r = 0.61
55	KEGG_TYPE_I_DIABETES_MELLITUS 46 genes · diabetes	0.000	0.000	NUTX:Taurine r = 0.30
56	HP_GENERALIZED_OSTEOPOROSIS 19 genes · osteoporosis	0.000	0.000	NUT:Clove oil r = 0.46
57	HP_PREMATURE_CORONARY_ARTERY_ATHEROSCLEROSIS 19 genes · atherosclerosis	0.000	0.000	YFY:昆布 r = 0.45

The reference board is auto-scanned from public gene-set databases (KEGG / Reactome / WikiPathways, etc.) and evaluated under the same frozen protocol; rankings are published directly. The overall board sorts by the 5-disease mean; disease tabs sort by that disease's single-module score (the atlas-increment column is always the 5-disease mean). p values are per-set permutation tests without cross-set multiple-testing correction (BH correction applies to the main nomination board). Inclusion is not an endorsement; gene-set authors are welcome to flag issues or claim their entry (author-verified entries can join the main nomination leaderboard).